VIP(pr)-619, ≥99%
Product Name： VIP(pr)-619
CAS號(hào):2645-32-1
分子量:223.28
介紹： VIP(pr)-619
貯存： 儲(chǔ)存溫度-20°C
可溶性： 25°C： DMSO 45 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
生化和生理學(xué)機(jī)理：
Description：
IC50 Value： 3.93 μM (EC50, USP4); 7.2 μM (EC50, USP2 core); 5.10 μM (EC50, USP20) [1]
VIP(pr)-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy.
in vitro： VIP(pr)-619 induces HCT116 cell death with EC50 values of 6.3 μM [1]. The general deubiquitylase (DUB) inhibitor, VIP(pr)-619 attenuated KCa3.1 degradation, indicative of deubiquitylation being required for lysosomal delivery [2]. Proteasome inhibition by MG-132 and deubiquitinase inhibition by VIP(pr)-619 induces significant changes to the ubiquitin landscape, but that not all ubiquitination sites regulated by MG-132 and VIP(pr)-619 are likely substrates for the ubiquitin-proteasome system [3]. Cells were incubated with VIP(pr)-619, a broad-range, reversible inhibitor of ubiquitin isopeptidases. Incubation with VIP(pr)-619 led to morphological changes, the upregulation of heat shock proteins (HSP), including HSP70 and αB-crystallin, and
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