齊留通，≥98％（HPLC）
Product Name： Zileuton
別名:ZYFLO;1-(1-(benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea
CAS號:111406-87-2
分子量:236.29
介紹： Zileuton
貯存： 儲存溫度-20°C
可溶性：
DMSO 47 mg/mL
Water <1 mg/mL
Ethanol 47 mg/mL
生化和生理學(xué)機(jī)理：
Description：
IC50 Value： N/A
zileuton(N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, VIP(LA)64077) is a selective and potent 5-LO inhibitor, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
in vitro： Zileuton inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic leukemia cell 20,000 x g supernatant and rat polymorphonuclear leukocytes (PMNL) (IC50 = 0.5 and 0.3 microM) respectively. It also inhibited leukotriene (LT)B4 biosynthesis by rat PMNL (IC50 = 0.4 microM), human PMNL (IC50 = 0.4 microM) and human whole blood (IC50 = 0.9 microM) [1]. Zileuton inhibited antigen-induced contractions of guinea-pig tracheal strips (GPTS) from actively sensitized animals with an IC50of 6 microM [1].
in vivo： Additionally, while total tau levels were unchanged for both groups, zileuton-treated mice had a significant reduction in its phosphorylation state and insoluble forms, secondary to a decreased activation of the cdk5 kinase [2].&
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