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| 產(chǎn)品編號(hào)：125316 |
| 產(chǎn)品名稱：Vc-MMAD, ≥99% |
| 產(chǎn)品CAS：1401963-17-4 |
| 規(guī)格含量：5MG |
| 產(chǎn)品價(jià)格：5000 |
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| 產(chǎn)品詳細(xì)介紹 |
Vc-MMAD, ≥99%
Product Name： Vc-MMAD
CAS號(hào):1401963-17-4
分子式:C70H104N12O14S
分子量:1369.71
貯存： 儲(chǔ)存溫度-20°C
可溶性： 25°C： DMSO
生化和生理學(xué)機(jī)理：
Description：
Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABVIP(LA)MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent： WO 2013068874 A1).
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