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| 產(chǎn)品基本信息 |
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| 產(chǎn)品編號(hào)：125591 |
| 產(chǎn)品名稱(chēng)：VcMMAE, ≥99% |
| 產(chǎn)品CAS：646502-53-6 |
| 規(guī)格含量：1MG |
| 產(chǎn)品價(jià)格：23,345.00 |
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| 產(chǎn)品詳細(xì)介紹 |
VcMMAE, ≥99%
Product Name： VcMMAE
CAS號(hào):646502-53-6
分子式:C68H105N11O15
分子量:1316.63
貯存： 儲(chǔ)存溫度-20°C
可溶性： DMSO
生化和生理學(xué)機(jī)理：
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy.
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